It's worth pointing out that it makes a big difference once you know the mechanism.

We don't do mechanical engineering based on the kind of thinking behind the miasma theory of disease. There is zero chance that we're suddenly going to realize that torque was wrong all along (I mean, it's moon-is-actually-made-of-cheese level improbable).

This is why reductionism is so powerful: not because it always readily provides answers, but because when you can do it your level of confidence can skyrocket.

So the point about hubris is well-advised, but there's an equal point to be made on the other side about unjustifiable skepticism. We know a lot now, and for very very very good reasons, in some cases. Confusing the cases where the understanding is spectacular with those where it is mediocre (e.g. how and whether diet affects cancer) is an enormous mistake (as per the Asimov quote).